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SYRE

Spyre Therapeutics Inc · NASDAQ NMS - GLOBAL MARKET · Biotechnology

$51.20+$2.22 (+4.53%)

Prices delayed up to 5 minutes

AC Intelligence

AC Intelligence

AC Intelligence for SYRE is being prepared.

Key Stats

Key Stats

Open

$48.97

Day High

$51.26

Day Low

$48.83

Prev Close

$48.98

Volume

0

Avg Volume

821.4K

Day Change

+$2.22

Change %

+4.53%

Fundamentals

Fundamentals

P/B

3.55

EPS (TTM)

$-2.55

Market Cap

$4.0B

52-Wk Range

$10.91 — $51.06

Earnings History

Insider Activity

Who Owns This Stock

Who Owns SYRE

Other58.9%99 holders
Quality / Compounder25.3%16 holders
Passive / Index15.4%8 holders
Dealer / Bank3.4%15 holders

Based on Q4 2025 13F filings + AC behavioral model

156 institutional holders

Top Holders

1.Fidelity Management
+27.0%$274053.3B
2.RTW INVESTMENTS, LP
+15.2%$136674.6B
3.Fairmount Funds Management LLC
$131633.0B
4.VR ADVISER, LLC
$120735.3B
5.Vanguard Group
$114681.0B
6.Capital International Investors
+46.0%$114415.6B
7.Fidelity Management
-51.9%$103711.5B
8.PERCEPTIVE ADVISORS LLC
$100547.8B
9.BlackRock, Inc.
$98732.0B
10.Driehaus Capital Management LLC
$94428.1B
11.COMMODORE CAPITAL LP
$78238.9B
12.State Street
$74130.6B
13.BlackRock, Inc.
$64848.0B
14.TCG Crossover Management, LLC
$62263.1B
15.TANG CAPITAL MANAGEMENT LLC
$61988.5B
16.JANUS HENDERSON GROUP PLC
$59217.3B
17.BRAIDWELL LP
$53550.0B
18.RA CAPITAL MANAGEMENT, L.P.
$53124.3B
19.Paradigm Biocapital Advisors LP
$48067.6B
20.Geode Capital Management
+34.0%$47058.5B

Institutional Pressure

Market Regime:Strong Risk-Off (-0.62)
SELLINGBUYING
Neutral
Other(58.9%)
Quality / Compounder(25.3%)
Holds through
Passive / Index(15.4%)
Holds
Dealer / Bank(3.4%)
Facilitating
Income / Defensive(0.4%)
Inflows (flight to yield)
Tactical / Macro(0.3%)
Reducing rapidly
Growth / Momentum(0.1%)
Likely trimming
Systematic / Quant(0.0%)
De-risking (mechanical)

41% passive + quality floor won't sell.

Updated daily · Based on Q4 2025 filings + AC behavioral model

Sentiment Signals

Sentiment Signals

Insider ActivityNo insider transactions in last 90 daysSEC Form 4
↑↑Analyst Consensus20 buy, 1 hold, 0 sellFinnhub
↑↑Inst. Flows178 increased/new, 37 decreased/exited (13F)AC 13F Analysis

Sources: SEC Form 4, Finnhub, AC 13F Analysis

On AcidCapitalist

On AcidCapitalist

No recent mentions of SYRE on AcidCapitalist.

Data provided by Finnhub. Prices delayed up to 5 minutes.