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UPB

Upstream Bio Inc · NASDAQ NMS - GLOBAL MARKET · Biotechnology

$9.84+$0.14 (+1.44%)

Prices delayed up to 5 minutes

AC Intelligence

AC Intelligence

AC Intelligence for UPB is being prepared.

Key Stats

Key Stats

Open

$9.87

Day High

$10.00

Day Low

$9.45

Prev Close

$9.70

Volume

0

Avg Volume

736.1K

Day Change

+$0.14

Change %

+1.44%

Fundamentals

Fundamentals

P/B

4.32

EPS (TTM)

$-2.66

Market Cap

$535M

52-Wk Range

$5.14 — $33.68

Earnings History

Insider Activity

Who Owns This Stock

Who Owns UPB

Other49.8%90 holders
Quality / Compounder24.6%13 holders
Passive / Index13.1%8 holders
Dealer / Bank5.5%13 holders
Tactical / Macro1.0%2 holders
Systematic / Quant0.7%3 holders

Based on Q4 2025 13F filings + AC behavioral model

135 institutional holders

Top Holders

1.Fidelity Management
$184511.0B
2.ORBIMED ADVISORS LLC
$154580.9B
3.Decheng Capital LLC
$85334.6B
4.NORGES BANK
$78263.9B
5.ENAVATE SCIENCES GP, LLC
$66780.9B
6.Vanguard Group
-3.6%$57916.7B
7.UBS Group AG
+563.2%$49028.1B
8.JANUS HENDERSON GROUP PLC
$41187.1B
9.BlackRock, Inc.
+46.3%$37381.9B
10.Altshuler Shaham Ltd
-5.3%$36422.8B
-45.5%$36097.1B
12.Omega Fund Management, LLC
$36008.9B
13.State Street
$35817.0B
14.VR ADVISER, LLC
$31746.4B
15.BlackRock, Inc.
-1.6%$25144.0B
16.WELLINGTON MANAGEMENT GROUP LLP
$24292.0B
17.Parkman Healthcare Partners LLC
$22658.3B
18.Pictet Asset Management Holding SA
$20991.0B
19.Woodline Partners LP
$20640.8B
$20362.5B

Institutional Pressure

Market Regime:Strong Risk-Off (-0.62)
SELLINGBUYING
Neutral
Other(49.8%)
Quality / Compounder(24.6%)
Holds through
Passive / Index(13.1%)
Holds
Dealer / Bank(5.5%)
Facilitating
Tactical / Macro(1.0%)
Reducing rapidly
Systematic / Quant(0.7%)
De-risking (mechanical)
Income / Defensive(0.1%)
Inflows (flight to yield)
Growth / Momentum(0.1%)
Likely trimming
Activist(0.1%)
May accumulate

38% passive + quality floor won't sell.

Updated daily · Based on Q4 2025 filings + AC behavioral model

Sentiment Signals

Sentiment Signals

Insider ActivityNo insider transactions in last 90 daysSEC Form 4
↑↑Analyst Consensus10 buy, 2 hold, 0 sellFinnhub
↑↑Inst. Flows140 increased/new, 47 decreased/exited (13F)AC 13F Analysis

Sources: SEC Form 4, Finnhub, AC 13F Analysis

On AcidCapitalist

On AcidCapitalist

No recent mentions of UPB on AcidCapitalist.

Data provided by Finnhub. Prices delayed up to 5 minutes.