§ BIOTECHNOLOGY
USD · BiotechnologySYRE
SPYRE THERAPEUTICS INC
USDSector · Biotechnology
§ 01 · PRICE
Price action
1D5D1M6MYTD1YMAX
§ 03 · SIGNAL STACK · WHAT THE INPUTS SAY
13F FLOW
196 increased/new, 62 decreased/exited (13F)
AC 13F Analysis
§ 05 · WHO OWNS IT
Top institutional holders
| Fund | Shares | % port | Δ Q/Q |
|---|---|---|---|
| Fidelity Management | 11.8M | 0.0% | +1% |
| BlackRock | 5.5M | 0.0% | −0% |
| RTW INVESTMENTS, LP | 4.2M | 2.1% | ±0% |
| Fairmount Funds Management LLC | 4.0M | 14.6% | ±0% |
| PERCEPTIVE ADVISORS LLC | 3.8M | n/a | +23% |
| VR ADVISER, LLC | 3.7M | 6.9% | ±0% |
◇ AC INTELLIGENCE
Top institutional owners for SYRE as of the most recent 13F reporting period (Q1 2026 · Period ended Mar 31). Δ Q/Q reflects share-count change vs. the prior filing — positive green means adding, negative red means trimming. Cross-reference with the ownership-mix bars below to see which strategy cohort is driving the flow.
§ 06 · WHO OWNS IT · BY STRATEGY
OTHER73.3% · 128 holders
QUALITY / COMPOUNDER25.2% · 16 holders
PASSIVE / INDEX10.6% · 10 holders
DEALER / BANK8.9% · 19 holders
INCOME / DEFENSIVE0.7% · 14 holders
TACTICAL / MACRO0.4% · 4 holders
SYSTEMATIC / QUANT0.2% · 7 holders
GROWTH / MOMENTUM0.1% · 1 holder
◇ AC INTELLIGENCE
Ownership mix by behavioral cohort. Top bars indicate which style of capital dominates the float — passive indexing, quality compounders, dealer/bank, systematic quant, etc. Big quality-compounder share means concentrated active conviction; heavy passive share means flows are dictated by index rebalances, not fundamentals.
§ 07 · INSIDER ACTIVITY · LAST 180 DAYS
NO INSIDER FILINGS
◇ AC INTELLIGENCE
No Form 4 filings on record for SYRE in the last 180 days.
§ 08 · COVERAGE · OUR RECENT NOTES
No notes mention SYRE yet.